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Multiple Endocrine Neoplasia (MEN) Syndromes

⚠️ Article status: Temporary high-yield summary

  • This article will be fully reviewed, expanded, and referenced in due course
  • Current content focuses on core principles and exam-relevant concepts
Syndrome Genetics Key tumours
MEN 1 MEN1 (tumour suppressor gene) 3Ps:

  • Parathyroid hyperplasia (→ hypercalcaemia) – often 1st presenting feature
  • Pancreatic tumour (e.g. gastrinoma, insulinoma)
  • Pituitary (prolactinoma is most common)
MEN 2A RET (proto-oncogene) 2Ps 1M:

  • Phaeochromocytoma
  • Medullary thyroid carcinoma
  • Parathyroid hyperplasia
MEN 2B RET (proto-oncogene) 1P 2Ms:

  • Phaeochromocytoma
  • Medullary thyroid carcinoma
  • Marfanoid habitus and mucosal neuromas

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