Guidelines

Pharmacological Management

BNF recommends a combination of 2 antiemetic drugs with different mechanisms of action in those with risk factors for post-operative nausea and vomiting.

Drugs used:

• 5HT₃-receptor antagonists (e.g. ondansetron, granisetron)
• Haloperidol and droperidol
• Prochlorperazine
• Dexamethasone
• Cyclizine is licensed for post-operative nausea and vomiting caused by opioids and general anaesthetics 

 
If a drug failed → switch to a different class of antiemetic.

References

Original Guideline