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Osteomyelitis

NICE BNF Treatment summaries Musculoskeletal system infections, antibacterial therapy

Article Last Updated:23/09/2025

Guidelines

Antibiotic Therapy

1st line:

Flucloxacillin for 6 weeks
Consider adding fusidic acid or rifampicin for the initial 2 weeks

Alternative:

If penicillin allergic: cllindamycin
If MRSA suspected: vancomycin / teicoplanin

References

Original Guideline

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