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Measles Exposure in Pregnancy

UK Health Security Agency Guidance National measles guidelines. Last updated: Apr 2026.

Article Last Updated:02/04/2026

Assessment and Investigation

Step 1 – assess immunity by clinical history

Immunity is assumed without further testing if ANY of the following:

Documented 2 doses of measles-containing vaccine (MMR or MMRV vaccine), or
The contact was born before 1970 in the UK (assumed to have natural immunity from past exposure)

Step 2 – assess immunity by blood test

If immunity cannot be assessed by history (e.g. patient is uncertain) → perform serum IgG testing

+ve IgG = immune
-ve IgG = non-immune

Management – Post-Exposure Prophylaxis (PEP)

PEP is only indicated for non-immune pregnant women.

There are 2 main components of PEP:

Immunoglobulin
- Immunocompetent → HNIG
- Immunosuppressed → IVIG
MMR vaccine – to be given after delivery

References

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