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Fungal Skin Infection

NICE CKS Fungal skin infection – scalp. Last revised: Feb 2025.

NICE CKS Fungal skin infection – body and groin. Last revised: Jul 2023.

NICE CKS Fungal skin infection – foot. Last revised: Jun 2023.

Management Overview

The choice of antifungal across the 3 fungal skin infections is similar but not the same, therefore this concise summary is made:

  • Scalp
    • 1st line: oral antifungal (terbinafine or griseofulvin)

 

  • Body + groin + foot (Athlete’s foot) are the same
    • 1st line: topical antifungal (terbinafine or imidazole)
    • Oral antifungal (1st line: terbinafine) reserved for severe / extensive disease

NB that this summary does not replace the below sections.

Scalp Infection

Management

Referral Criteria

  • Suspected kerion – urgent referral
  • Unsuccessful treatment in primary care
  • Severe / extensive / recurrent infection
  • Immunocompromised

General Management / Self-Care Advice

Self management:

  • Soften any surface crusts (e.g. moistened dressings), then gently tease away

Measures to prevent spread and transmission:

  • Discard / disinfect objects that can transmit fungal spores (e.g. hats, scarves, hairbrushes, combs, pillows, blankets, scissors)
  • Do not share towels, and wash frequently
  • If household pet is the suspected source, assess and treat by a vet

Antifungal Treatment

Indications to Treat

Offer oral antifungal if any of the following:

  • +ve microscopy or culture of the skin and hair
  • -ve mycology but suggestive clinical features (but arrange repeat skin and hair sampling)
  • Strong clinical suspicion before mycology results are back

Choice of Antifungal

1st line: oral terbinafine or griseofulvin +/- topical antifungal (e.g. ketoconazole shampoo, imidazole cream)

  • Blind treatment (before culture results available)
    • If person lives in urban areaterbinafine for 4 weeks
    • If person lives in rural areagriseofulvin for 4-8 weeks

 

  • Cultured guided treatment (adjust treatment accordingly)
    • If Trichophyton tonsuransterbinafine
    • If Microsporum species → griseofulvin

2nd line antifungal: oral itraconazole

Follow Up

Review the patient 4-8 weeks after completing oral antifungal therapy.

If signs of persistent / recurrent infection, or hair regrowth do not occur → repeat skin and hair sampling for fungal microscopy and culture.

Body and Groin Infection

Management

General Management / Self-Care Advice

Self management:

  • Wear loose-fitting clothes made of cotton or material designed to keep moisture away from the skin
  • Wash affected skin daily + dry the skin after washing (esp. in the skin folds)
  • Avoid scratching affected skin (as this may spread the infection to other sites)

Measures to prevent spread and transmission:

  • Do not share towels, and wash frequently
  • Wash clothes and bed linen frequently

If a child is affected, it is NOT necessary to exclude them from school or nursery

Antifungal Treatment

Mild Non-Extensive Disease

1st line: topical antifungal cream

  • Terbinafine cream (only if >12 y/o), or
  • Imidazole (e.g. clotrimazole, miconazole, econazole) (for all ages)

Consider a mildly potent topical corticosteroid (e.g. hydrocortisone 1%) if there is associated marked inflammation.

In children, 1st line is topical imidazole.

Topical terbinafine cream is NOT licensed in those <12 y/o

Severe / Extensive Disease

Consider oral antifungal

  • 1st line: terbinafine
  • 2nd line: itraconazole / griseofulvin

Foot Infection (Athlete’s Foot)

Management

General Management / Self-Care Advice

Self management:

  • Foot hygiene
    • Wear well-fitting, non-occlusive footwear that keeps the feet cool and dry
    • Wear different pair of shoes every 2-3 days
    • Wear cotton, absorbent socks
    • Dry the skin after washing the feet (esp. between the toes)
  • Avoid scratching affected skin (as this may spread the infection to other sites)

Measures to prevent spread and transmission:

  • Replace old footwear which could be contaminated with fungal spores
  • Do not share towels, and wash frequently
  • Wear protective footwear when using communal bathing places, locker rooms, gyms

If a child is affected, it is NOT necessary to exclude them from school or nursery

Antifungal Treatment

Mild Non-Extensive Disease

1st line: topical antifungal cream

  • Terbinafine cream (only if >12 y/o), or
  • Imidazole (e.g. clotrimazole, miconazole, econazole) (for all ages)

Consider a mildly potent topical corticosteroid (e.g. hydrocortisone 1%) if there is associated marked inflammation.

2nd line options

  • OTC undecenoic acid cream, or
  • Topical preparations containing tolnaftate

In children, 1st line is topical imidazole.

Topical terbinafine cream is NOT licensed in those <12 y/o

Severe / Extensive Disease

Consider oral antifungal

  • 1st line: terbinafine
  • 2nd line: itraconazole / griseofulvin

References



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