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Obsessive-Compulsive Disorder (OCD)

NICE Clinical guideline [CG31] Obsessive-compulsive disorder and body dysmorphic disorder: treatment. Published: Nov 2005. Last reviewed: Jul 2014.

Obsessive-Compulsive Disorder (OCD)

General Psychiatry Article Disclaimer

    • DSM-5 criteria or ICD-11 diagnostic requirements are used to structure the Clinical Features and Diagnosis section. The classification system used is selected according to its clarity and suitability for non-specialist learning.
    • The criteria are summarised and simplified rather than reproduced in full, while preserving their original diagnostic meaning.
  • Where appropriate, a student-friendly pattern-recognition summary is provided to highlight the most clinically and exam-relevant features.

Exam tip (re-psychiatry questions)

  • Do not attempt to memorise every DSM-5 or ICD-11 criterion word-for-word. However, it is important to read through the criteria and become familiar with the key symptom clusters, duration thresholds, exclusions, and distinguishing features highlighted in this article.
  • Exam questions may not provide every feature required to meet the full diagnostic criteria. Familiarity with the criteria can help one recognise the most likely diagnosis, exclude important alternatives, and narrow the differential diagnosis.

Screening

NICE recommends the following:

Indications to screen for OCD Individuals at higher risk of OCD (e.g. those with depression, anxiety, alcohol or substance misuse, body dysmorphic disorder, or eating disorder)

Individuals attending dermatology clinics

Screening method Explore the possibility of comorbid OCD by asking the following direct questions:
  • “Do you wash or clean a lot?”
  • “Do you check things a lot?”
  • “Are there any thoughts that keep bothering you that you would like to get rid of but cannot?”
  • “Do your daily activities take a long time to finish?”
  • “Are you concerned about putting things in a special order, or are you very upset by mess?”
  • “Do these problems trouble you?”

Clinical Features and Diagnosis

High-yield pattern recognition for OCD:

  • Presence of obsessions and/or compulsions
    • Obsession: recurrent, intrusive and unwanted thoughts, images or urges that cause anxiety / distress (e.g. contamination, fear of harm, unwanted sexual/religious thoughts, need for symmetry/order)
    • Compulsion: repetitive behaviours or mental acts performed to reduce anxiety or prevent a feared event (e.g. excessive washing / cleaning, repeated checking, counting, ordering, repeating words/prayers mentally)
  • The behaviours are often excessive or not realistically connected to what they are intended to prevent
  • Symptoms are time-consuming (>1 hour / day) or cause clinically significant distress or impairment
  • Symptoms are not due to a substance/medical condition and are not better explained by another mental disorder

Classic exam pattern: intrusive unwanted thought → marked anxiety → repetitive act to reduce the anxiety

As per the DSM-5 criteria, ALL of the following must be met: [Ref]

Diagnostic criteria Criteria description
Presence of obsession and/or compulsion Obsession (both must be present):
  1. Recurrent and persistent thoughts, urges or images that are experienced, at some time during the disturbance, as intrusive, unwanted, and that in most individuals cause marked anxiety or distress
  2. The individual attempts to ignore or suppress such thoughts, urges, or images, or to neutralise them with some thought or action (i.e. by performing a compulsion)

Compulsion (both must be present):

  1. Repetitive behaviours (e.g. hand washing, ordering, checking) or mental acts (e.g. praying, counting, repeating words silently) that the person feels driven to perform in response to an obsession, or according to the rules that must be applied rigidly
  2. The behaviours or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation
    • However, these behaviours or mental acts either are not connected in a realistic way with what they are designed to neutralise or prevent or are clearly excessive
Impact
  • The obsessions or compulsions are time-consuming (e.g. take more than 1 hour per day), or
  • Cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
Exclusion The disturbance is not better explained by or attributable to:
  • Another mental disorder, such as
    • Excessive worries in generalised anxiety disorder
    • Preoccupation with appearance in body dysmorphic disorder
    • Difficulty discarding or parting with possessions in hoarding disorder
    • Hair pulling in trichotillomania (hair-pulling disorder)
    • Skin picking in excoriation (skin-picking) disorder
    • Stereotypies in stereotypic movement disorder
    • Ritualised eating behaviour in eating disorders
    • Preoccupation with substances or gambling in substance-related and addictive disorders
    • Sexual urges or fantasies in paraphilic disorders
    • Impulses in disruptive, impulse-control, and conduct disorders
    • Guilty ruminations in major depressive disorder
    • Thought insertion or delusional preoccupations in schizophrenia spectrum and other psychotic disorders
    • Repetitive patterns of behaviour in autism spectrum disorder
  • Physiological effects of a substance
  • General medical condition

Management

For those who are diagnosed with OCD, it is important to assess the risk of self-harm and suicide (esp. if there is concurrent depression)

Part of the risk assessment should include the impact of their compulsive behaviours on themselves or others

Management depends on 1) age and 2) degree of functional impairment caused by OCD

Adults

Degree of functional impairment 1st line management Step up
Mild 1st line: low-intensity CBT, including exposure and response prevention
  • Brief individual CBT using structured self-help materials
  • Brief individual CBT by telephone
  • Group CBT
Manage as moderate functional impairment (i.e. CBT or SSRI)
Moderate Offer either (informed by patient’s preference):
  • Intensive CBT, including exposure and response prevention, OR
  • SSRI (fluoxetine / fluvoxamine / paroxetine / sertraline / citalopram)
MDT review:
  • If inadequate response → combination treatment (CBT + SSRI)
  • No response to SSRI or patient did not engage with CBTswitch to different SSRI or clomipramine
Severe Offer combination therapy of:
  • Intensive CBT, including exposure and response prevention, PLUS
  • SSRI (fluoxetine / fluvoxamine / paroxetine / sertraline / citalopram)
First, switch to a different SSRI or clomipramine

If ineffective → refer to specialist MTD, which may consider

  • Additional CBT
  • Adding an antipsychotic to SSRI / clomipramine
  • SSRI + clomipramine

Do NOT routinely offer anxiolytics to treat OCD. Only consider for short-term use with caution to counter the early activating side effects of SSRIs.

Do NOT use the following to treat OCD:

  • TCA that is other than clomipramine
  • SNRI (e.g. duloxetine, venlafaxine)
  • MOA-I
  • Antipsychotics as a monotherapy

Children and Young People (<18 y/o)

Degree of functional impairment 1st line management Step up
Mild 1st line: guided self-help + support and information for family or carers Developmentally adapted CBT that involves the family or carers
Moderate to severe 1st line: developmentally adapted CBT, including exposure and response prevention that involves the family or carers Consider adding an SSRI to CBT, with specific arrangements for close monitoring

References

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