Fungal Skin Infection
NICE CKS Fungal skin infection – scalp. Last revised: Feb 2025.
NICE CKS Fungal skin infection – body and groin. Last revised: Jul 2023.
NICE CKS Fungal skin infection – foot. Last revised: Jun 2023.
Management Overview
The choice of antifungal across the 3 fungal skin infections is similar but not the same, therefore this concise summary is made:
- Scalp
- 1st line: oral antifungal (terbinafine or griseofulvin)
- Body + groin + foot (Athlete’s foot) are the same
- 1st line: topical antifungal (terbinafine or imidazole)
- Oral antifungal (1st line: terbinafine) reserved for severe / extensive disease
NB that this summary does not replace the below sections.
Scalp Infection
Management
Referral Criteria
- Suspected kerion – urgent referral
- Unsuccessful treatment in primary care
- Severe / extensive / recurrent infection
- Immunocompromised
General Management / Self-Care Advice
Self management:
- Soften any surface crusts (e.g. moistened dressings), then gently tease away
Measures to prevent spread and transmission:
- Discard / disinfect objects that can transmit fungal spores (e.g. hats, scarves, hairbrushes, combs, pillows, blankets, scissors)
- Do not share towels, and wash frequently
- If household pet is the suspected source, assess and treat by a vet
Antifungal Treatment
Indications to Treat
Offer oral antifungal if any of the following:
- +ve microscopy or culture of the skin and hair
- -ve mycology but suggestive clinical features (but arrange repeat skin and hair sampling)
- Strong clinical suspicion before mycology results are back
Choice of Antifungal
1st line: oral terbinafine or griseofulvin +/- topical antifungal (e.g. ketoconazole shampoo, imidazole cream)
- Blind treatment (before culture results available)
- If person lives in urban area → terbinafine for 4 weeks
- If person lives in rural area → griseofulvin for 4-8 weeks
- Cultured guided treatment (adjust treatment accordingly)
- If Trichophyton tonsurans → terbinafine
- If Microsporum species → griseofulvin
2nd line antifungal: oral itraconazole
Follow Up
Review the patient 4-8 weeks after completing oral antifungal therapy.
If signs of persistent / recurrent infection, or hair regrowth do not occur → repeat skin and hair sampling for fungal microscopy and culture.
Body and Groin Infection
Management
General Management / Self-Care Advice
Self management:
- Wear loose-fitting clothes made of cotton or material designed to keep moisture away from the skin
- Wash affected skin daily + dry the skin after washing (esp. in the skin folds)
- Avoid scratching affected skin (as this may spread the infection to other sites)
Measures to prevent spread and transmission:
- Do not share towels, and wash frequently
- Wash clothes and bed linen frequently
If a child is affected, it is NOT necessary to exclude them from school or nursery
Antifungal Treatment
Mild Non-Extensive Disease
1st line: topical antifungal cream
- Terbinafine cream (only if >12 y/o), or
- Imidazole (e.g. clotrimazole, miconazole, econazole) (for all ages)
Consider a mildly potent topical corticosteroid (e.g. hydrocortisone 1%) if there is associated marked inflammation.
In children, 1st line is topical imidazole.
Topical terbinafine cream is NOT licensed in those <12 y/o
Severe / Extensive Disease
Consider oral antifungal
- 1st line: terbinafine
- 2nd line: itraconazole / griseofulvin
Foot Infection (Athlete’s Foot)
Management
General Management / Self-Care Advice
Self management:
- Foot hygiene
- Wear well-fitting, non-occlusive footwear that keeps the feet cool and dry
- Wear different pair of shoes every 2-3 days
- Wear cotton, absorbent socks
- Dry the skin after washing the feet (esp. between the toes)
- Avoid scratching affected skin (as this may spread the infection to other sites)
Measures to prevent spread and transmission:
- Replace old footwear which could be contaminated with fungal spores
- Do not share towels, and wash frequently
- Wear protective footwear when using communal bathing places, locker rooms, gyms
If a child is affected, it is NOT necessary to exclude them from school or nursery
Antifungal Treatment
Mild Non-Extensive Disease
1st line: topical antifungal cream
- Terbinafine cream (only if >12 y/o), or
- Imidazole (e.g. clotrimazole, miconazole, econazole) (for all ages)
Consider a mildly potent topical corticosteroid (e.g. hydrocortisone 1%) if there is associated marked inflammation.
2nd line options
- OTC undecenoic acid cream, or
- Topical preparations containing tolnaftate
In children, 1st line is topical imidazole.
Topical terbinafine cream is NOT licensed in those <12 y/o
Severe / Extensive Disease
Consider oral antifungal
- 1st line: terbinafine
- 2nd line: itraconazole / griseofulvin
References