Total Live Articles: 494

Post-Traumatic Stress Disorder (PTSD)

NICE guideline [NG116] Post-traumatic stress disorder. Published: Dec 2018.

Post-Traumatic Stress Disorder (PTSD)

General Psychiatry Article Disclaimer

  • DSM-5 criteria or ICD-11 diagnostic requirements are used to structure the Clinical Features and Diagnosis section. The classification system used is selected according to its clarity and suitability for non-specialist learning.
  • The criteria are summarised and simplified rather than reproduced in full, while preserving their original diagnostic meaning.
  • Where appropriate, a student-friendly pattern-recognition summary is provided to highlight the most clinically and exam-relevant features.

Exam tip (re-psychiatry questions)

  • Do not attempt to memorise every DSM-5 or ICD-11 criterion word-for-word. However, it is important to read through the criteria and become familiar with the key symptom clusters, duration thresholds, exclusions, and distinguishing features highlighted in this article.
  • Exam questions may not provide every feature required to meet the full diagnostic criteria. Familiarity with the criteria can help one recognise the most likely diagnosis, exclude important alternatives, and narrow the differential diagnosis.

Causes

PTSD develops after exposure to actual or threatened death, serious injury, or sexual violence [Ref]

Exposure may occur through: [Ref]

  • Directly experiencing the traumatic event
  • Witnessing the event occurring to another person
  • Learning that the event occurred to a close family member or close friend
  • Repeated or extreme occupational exposure to distressing details of traumatic events (e.g. emergency responders)

NICE noted the following specific examples:

  • Serious accidents
  • Physical and sexual assault
  • Abuse, including childhood or domestic abuse
  • Work-related exposure to trauma, including remote exposure
  • Trauma related to serious health problems or childbirth experiences (for example, intensive care admission or neonatal death)
  • War and conflict
  • Torture

Clinical Features and Diagnosis

High-yield pattern recognition for PTSD:

  • Onset of stress symptoms after a traumatic event
  • Symptoms must be present across all 4 clusters, including
    • Intrusion (e.g. re-experiencing, intrusive memories, trauma-related nightmares or flashbacks)
    • Avoidance (e.g. avoiding thoughts, conversations, people, places or activities associated with the trauma)
    • Negative cognition and mood (e.g. persistent guilt or self-blame, negative beliefs, emotional detachment or loss of interest)
    • Arousal and reactivity  (e.g. hyperarousal, hypervigilance, exaggerated startle response, irritability, poor sleep or impaired concentration)
  • Which lasts for >1 month
  • That is causing significant distress or functional impairment
  • Not better explained by a different underlying cause

According to the DSM-5 criteria, PTSD can be clinically diagnosed when ALL the following criteria are met: [Ref]

Diagnostic criteria Criteria description
Exposure to a traumatic event Exposure to actual or threatened death, serious injury, or sexual violence (see above for examples)
Presence of PTSD symptoms To diagnose PTSD, symptoms across all 4 clusters is necessary:
  1. Intrusion symptoms (at least 1 of the following)
    • Recurrent, involuntary and distressing memories
    • Recurrent trauma-related distressing dreams
    • Dissociative reactions or flashbacks
    • Intense or prolonged psychological distress when exposed to trauma-related reminders
    • Marked physiological reactions to trauma-related reminders
  2. Avoidance symptoms (at least 1 of the following)
    • Avoidance of trauma-related memories, thoughts or feelings
    • Avoidance of external reminders, such as people, places, conversations, activities, objects or situations
  3. Negative alterations in cognition and mood (at least 2 of the following)
    • Inability to recall an important aspect of the trauma due to dissociative amnesia
    • Persistent negative beliefs or expectations about oneself, others or the world
    • Persistent distorted beliefs about the cause or consequences of the trauma, leading to inappropriate blame
    • Persistent negative emotional state
    • Markedly reduced interest or participation in significant activities
    • Feelings of detachment or estrangement from others
    • Persistent inability to experience positive emotions
  4. Alterations in arousal and reactivity (at least 2 of the following)
    • Irritability or angry outbursts
    • Reckless or self-destructive behaviour
    • Hypervigilance
    • Exaggerated startle response
    • Difficulty concentrating
    • Sleep disturbance
Duration Symptoms must persist for >1 month
Presence of functional impairment The symptoms must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
Exclusion of other causes The disturbance must not be attributable to ANY of the following:
  • Substance use (e.g. alcohol, medications)
  • Medical condition

NICE noted the following specific symptoms that can be seen in PTSD:

  • Re-experiencing
  • Avoidance
  • Hyperarousal (including hypervigilance, anger and irritability)
  • Negative alterations in mood and thinking
  • Emotional numbing
  • Dissociation
  • Emotional dysregulation
  • Interpersonal difficulties or problems in relationships
  • Negative self-perception (including feeling diminished, defeated or worthless)

PTSD vs Acute Stress Reaction

Key differentiating factors between acute stress reaction and PTSD: [Ref1][Ref2]

Acute stress reaction PTSD
Symptom duration 3 days to 1 month >1 month
Symptom requirements ≥9 of 14 symptoms, taken from any combination of intrusion, negative mood, dissociation, avoidance and arousal Requires a minimum number from each of 4 mandatory symptom clusters

Also see the Acute Stress Reaction article.

Management

Adults (≥18 y/o)

Standard management:

Category Indications Description
Psychological therapy 1st line management for PTSD Offer individual trauma-focused CBT interventions, including:
  • Cognitive processing therapy
  • Cognitive therapy for PTSD
  • Narrative exposure therapy
  • Prolonged exposure therapy

Eye movement desensitisation and reprocessing (EMDR) can be considered / offered in non-combat-related trauma in the following scenarios:

  • Consider if 1-3 months post-traumatic event AND preference for EMDR
  • Offer if >3 months post-traumatic event

Rationale: EMDR is not excluded from use in combat trauma-related PTSD, but its research base and clinical implementation are less extensive compared to civilian / non-combat trauma.

Do NOT offer psychologically-focused debriefing

Pharmacological management Only indicated if:
  • Patient prefers to have drug treatment, or
  • Psychological therapy is ineffective
If pharmacological management is indicated:
  • 1st line: SSRI (e.g. sertraline) or venlafaxine
  • Consider antipsychotics (e.g. risperidone) in addition to psychological therapies to manage symptoms if:
    • Disabling symptoms and behaviours (e.g. severe hyperarousal or psychotic symptoms) and
    • Failed to respond to other drug or psychological treatments

Do not offer benzodiazepines or any other medications to prevent PTSD.

Children (<18 y/o)

Offer psychological therapy

  • ​​​1st line: individual trauma-focused CBT
    • Consider group trauma-focused CBT if the event led to large-scale shared trauma
  • 2nd line: eye movement desensitisation and reprocessing (EMDR)
    • Indicated after >3 months of traumatic event AND if there is a lack of engagement / response to CBT

Do NOT offer psychologically-focused debriefing

Do NOT offer pharmacological management to prevent or treat PTSD in those who are <18 y/o

References

​​​​​​​

Share Your Feedback Below

Disclaimer

We’re actively expanding Guideline Genius to cover the full UKMLA content map. Therefore, you may notice some conditions not uploaded yet, or articles that currently focus on diagnosis and management for now.

We are also continuously reviewing and updating existing content to ensure accuracy and alignment with current guidelines. Some earlier articles are undergoing revision as part of this process. Once all content has been fully reviewed, this will be clearly communicated on the platform.

For updates, follow us on Instagram @guidelinegenius.

We welcome any feedback or suggestions via the anonymous feedback box at the bottom of each article and will do our best to respond promptly.

Thank you for your support.
The Guideline Genius Team

UK medical guidelines made easy. From guidelines to genius in minutes!

Quick Links

Cookie Policy

Social Media

© 2026 GUIDELINE GENIUS LTD

Stay Updated withGuideline Genius

Sign up to be notified when our newsletter launches, covering major guideline updates, article updates, and future UKMLA resources.