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Postpartum Mental Health Problems

NICE clinical guideline [CG192] Antenatal and postnatal mental health: clinical management and service guidance. Last updated: Feb 2020.

Royal College of Psychiatrists CR232 Perinatal Mental Health Services: Recommendations for the provision of services for childbearing women. Sep 2021

Postpartum Mental Health Problems

Postpartum mental health problems include:

  • Postpartum blues (maternity blues / baby blues)
  • Postpartum depression / postnatal depression
  • Postpartum psychosis

Postpartum Blues (Maternity Blues / Baby Blues)

Definition

Postpartum blues is a common, mild, transient and self-limiting postpartum mood disturbance characterised by mood lability and other mild depressive symptoms developing shortly after childbirth [Ref]

It is NOT classified as a distinct mental disorder

Clinical Features and Recognition

[Ref1][Ref2]

Timing Usually develops within the first few days after delivery, commonly around days 3-4

Usually resolves spontaneously within ~10 days and should resolve within 2 weeks

Clinical features Possible mood changes include:

  • Weepiness
  • Low mood
  • Mood lability
  • Irritability
  • Anxiety
  • Sleep disturbance
  • Poor concentration

Postpartum blues can be recognised by:

  • Mild mood changes (no obvious functional impairment) beginning within the first few days after childbirth
  • Symptoms that spontaneously resolve within 2 weeks (without treatment)

Postpartum blues is associated with an increased risk of subsequent postpartum depression

Management

No specific treatment is usually required as postpartum blues is temporary and self-limiting [Ref1][Ref2]

Provide reassurance, rest and practical / emotional support

Postpartum Depression

Clinical Features and Recognition

Disclaimer:

DSM-5 criteria do not classify postpartum depression as a separate disorder. Instead, the specifier “with peripartum onset” can be applied to a major depressive episode that begins during pregnancy or within 4 weeks after delivery

However, the clinical term “postpartum depression / postnatal depression” is still used for depression occurring after childbirth.

[Ref1][Ref2]

Timing Onset: often begins within the first 1-2 months after childbirth, but may develop several months later

Duration: depressive symptoms persist for ≥2 weeks

Symptoms may also begin during pregnancy and continue after delivery

Clinical features Key features:

  • Depressed mood
  • Anhedonia
  • Sleep disturbance beyond what is needed for baby care
  • Irritability
  • Feeling unable to cope
  • Excessive anxiety or worry about the baby’s health, feeding or safety

Postpartum depression should be suspected if:

  • Depressive symptoms persist for ≥2 weeks, particularly when apparent postpartum blues fails to resolve
  • Symptoms can cause significant distress and/or functional impairment

Unlike postpartum blues, postpartum depression is more persistent and clinically significant

Management

Management depends on the severity of depression:

Depression severity Recommended management
Subthreshold / mild / moderate Facilitated self-help

If mild depression + history of severe depression → consider an antidepressant (TCA / SSRI / SNRI)

Moderate to severe High-intensity psychological intervention (e.g. CBT)

Consider an antidepressant (TCA / SSRI / SNRI) if the patient:

  • Prefers medication, or
  • Declines psychological therapy, or
  • Does not improve with psychological intervention alone

Consider combined psychological therapy + antidepressant if there is limited response to either alone

Choice of antidepressants:

  • NICE recommends considering a TCA, SSRI or SNRI when antidepressant treatment is indicated
  • NICE does NOT name a single ‘preferred’ antidepressant, instead emphasises personalised prescribing principles based on safety and past efficacy
    • A primary factor in choosing a drug is the woman’s previous response to the medication. If a drug has worked well for her in the past, clinicians must weigh the risks of switching or stopping that previously effective medication
    • The lowest effective dose and a single drug are preferred
    • Specific drug warnings: the guideline noted paroxetine and venlafaxine are particularly associated with discontinuation symptoms in the mother and neonatal adaptation syndrome in the baby
  • As per NHS SPS: [Ref]
    • Sertraline or paroxetine are the preferred SSRIs during breastfeeding
    • Imipramine or nortriptyline are the preferred TCAs during breastfeeding

Postpartum Psychosis

Definition

Postpartum psychosis is a psychiatric emergency with sudden onset after childbirth, characterised by psychotic symptoms, often accompanied by manic and/or depressive symptoms

Clinical Features and Recognition

Postpartum psychosis can occur in women with no previous psychiatric history [Ref]

Important risk factors include: [Ref]

  • Bipolar I disorder (postpartum psychosis is strongly associated with bipolar)
  • Previous postpartum psychosis
  • Close family history of postpartum psychosis

[Ref]

Timing Usually develops within the first 2 weeks after childbirth, often within the first few days
Clinical features Core symptom: psychosis

  • Delusion
  • Hallucinations
  • Disorganised thought / behaviour

Other symptoms:

  • Mania (e.g. elevated mood, increased activity / talkativeness, racing thoughts, reduced need for sleep)
  • Depression (e.g. low mood, tearfulness)
  • Severe confusion, agitation
  • Rapidly changing mood or behaviour

Management

Postpartum psychosis is a psychiatric emergency

Immediate referral to secondary mental health service (preferably perinatal specialist)

  • Patients often require inpatient care
  • If inpatient care is necessary → admit in a specialist mother and baby unit

Pharmacological treatment is specialist-led and usually involves: [Ref]

  • Antipsychotics
  • Mood stabiliser
  • Combination treatment may be required

References

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